Assay Detail
Binding
CHEMBL5442207
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PDSP Secondary Binding target: TSPO - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Category | PDSP assay |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
EUbOPEN Chemogenomics Library - PDSP Secondary Binding
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 5.89 | 6.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3716980 | — | — | 1 | 6.95 |
| CHEMBL428504 | — | — | 1 | 6.74 |
| CHEMBL426559 | LAROPIPRANT | 4.0 | 1 | 6.54 |
| CHEMBL1766103 | — | — | 1 | 6.28 |
| CHEMBL2110363 | — | — | 1 | 6.10 |
| CHEMBL256470 | — | — | 1 | 6.10 |
| CHEMBL2435402 | — | — | 1 | 6.09 |
| CHEMBL405355 | NIGULDIPINE | 2.0 | 1 | 6.02 |
| CHEMBL2030155 | — | — | 1 | 6.01 |
| CHEMBL21283 | — | — | 1 | 6.01 |
| CHEMBL487553 | — | — | 1 | 6.01 |
| CHEMBL540612 | — | — | 1 | 5.93 |
| CHEMBL2181226 | — | — | 1 | 5.89 |
| CHEMBL3086703 | — | — | 1 | 5.86 |
| CHEMBL23327 | PURVALANOLA | — | 1 | 5.82 |
| CHEMBL5087624 | — | — | 1 | 5.79 |
| CHEMBL3342358 | — | — | 1 | 5.78 |
| CHEMBL475903 | — | — | 1 | 5.73 |
| CHEMBL3410223 | — | — | 1 | 5.71 |
| CHEMBL1200492 | NEFAZODONE HYDROCHLORIDE | 4.0 | 1 | 5.70 |
| CHEMBL2103873 | MACITENTAN | 4.0 | 1 | 5.67 |
| CHEMBL38182 | — | — | 1 | 5.52 |
| CHEMBL225155 | — | — | 1 | 5.51 |
| CHEMBL2386353 | — | — | 1 | 5.48 |
| CHEMBL9506 | DEVAZEPIDE | 2.0 | 1 | 5.48 |
| CHEMBL531742 | — | — | 1 | 5.40 |
| CHEMBL3545181 | TIOTROPIUM BROMIDE | 4.0 | 1 | 5.37 |
| CHEMBL5077459 | — | — | 1 | 5.32 |
| CHEMBL1472 | PROTIRELIN | 4.0 | 1 | - |
| CHEMBL1558 | PRAZOSIN HYDROCHLORIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3716980 | — | Ki | = | 111.12 | nM | 6.95 |
| CHEMBL428504 | — | Ki | = | 183.97 | nM | 6.74 |
| CHEMBL426559 | LAROPIPRANT | Ki | = | 286.42 | nM | 6.54 |
| CHEMBL1766103 | — | Ki | = | 522.4 | nM | 6.28 |
| CHEMBL2110363 | — | Ki | = | 789.49 | nM | 6.10 |
| CHEMBL256470 | — | Ki | = | 799.1 | nM | 6.10 |
| CHEMBL2435402 | — | Ki | = | 802.97 | nM | 6.09 |
| CHEMBL405355 | NIGULDIPINE | Ki | = | 952.9 | nM | 6.02 |
| CHEMBL2030155 | — | Ki | = | 969.17 | nM | 6.01 |
| CHEMBL21283 | — | Ki | = | 974.88 | nM | 6.01 |
| CHEMBL487553 | — | Ki | = | 968.95 | nM | 6.01 |
| CHEMBL540612 | — | Ki | = | 1179.92 | nM | 5.93 |
| CHEMBL2181226 | — | Ki | = | 1301.66 | nM | 5.89 |
| CHEMBL3086703 | — | Ki | = | 1378.79 | nM | 5.86 |
| CHEMBL23327 | PURVALANOLA | Ki | = | 1515.83 | nM | 5.82 |
| CHEMBL5087624 | — | Ki | = | 1631.92 | nM | 5.79 |
| CHEMBL3342358 | — | Ki | = | 1662.07 | nM | 5.78 |
| CHEMBL475903 | — | Ki | = | 1879.32 | nM | 5.73 |
| CHEMBL3410223 | — | Ki | = | 1951.86 | nM | 5.71 |
| CHEMBL1200492 | NEFAZODONE HYDROCHLORIDE | Ki | = | 1986.32 | nM | 5.70 |
| CHEMBL2103873 | MACITENTAN | Ki | = | 2118.36 | nM | 5.67 |
| CHEMBL38182 | — | Ki | = | 3028.31 | nM | 5.52 |
| CHEMBL225155 | — | Ki | = | 3115.3 | nM | 5.51 |
| CHEMBL2386353 | — | Ki | = | 3298.37 | nM | 5.48 |
| CHEMBL9506 | DEVAZEPIDE | Ki | = | 3332.73 | nM | 5.48 |
| CHEMBL531742 | — | Ki | = | 4012.36 | nM | 5.40 |
| CHEMBL3545181 | TIOTROPIUM BROMIDE | Ki | = | 4286.47 | nM | 5.37 |
| CHEMBL5077459 | — | Ki | = | 4781.34 | nM | 5.32 |
| CHEMBL1472 | PROTIRELIN | Ki | > | 10000.0 | nM | - |
| CHEMBL1558 | PRAZOSIN HYDROCHLORIDE | Ki | > | 10000.0 | nM | - |