Assay Detail
Functional
CHEMBL5442690
Review assay metadata, readout intent, target linkage, and publication context from the same page.
GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1
15
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HTLA |
| Category | GPCR beta-arrestin recruitment assay |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
EUbOPEN Chemogenomics Library - GPCR Dose-Respose
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.59 | 9.22 |
| EC50 | 1 | 5.90 | 5.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2440454 | — | — | 1 | 9.22 |
| CHEMBL1513 | IRBESARTAN | 4.0 | 1 | 8.52 |
| CHEMBL1017 | TELMISARTAN | 4.0 | 1 | 8.27 |
| CHEMBL130896 | — | — | 1 | 7.78 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.60 |
| CHEMBL484929 | — | — | 1 | 5.90 |
| CHEMBL1256876 | — | — | 1 | 5.50 |
| CHEMBL1766103 | — | — | 1 | 5.44 |
| CHEMBL329650 | — | — | 1 | 5.43 |
| CHEMBL1474387 | — | — | 1 | 5.38 |
| CHEMBL531742 | — | — | 1 | 5.36 |
| CHEMBL103769 | — | — | 1 | 5.32 |
| CHEMBL4743495 | — | — | 1 | 5.20 |
| CHEMBL238804 | SELEXIPAG | 4.0 | 1 | - |
| CHEMBL1200517 | DIHYDROERGOTAMINE MESYLATE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2440454 | — | IC50 | = | 0.6063 | nM | 9.22 |
| CHEMBL1513 | IRBESARTAN | IC50 | = | 2.999 | nM | 8.52 |
| CHEMBL1017 | TELMISARTAN | IC50 | = | 5.398 | nM | 8.27 |
| CHEMBL130896 | — | IC50 | = | 16.59 | nM | 7.78 |
| CHEMBL191 | LOSARTAN | IC50 | = | 24.86 | nM | 7.60 |
| CHEMBL484929 | — | EC50 | = | 1259.37 | nM | 5.90 |
| CHEMBL1256876 | — | IC50 | = | 3130.24 | nM | 5.50 |
| CHEMBL1766103 | — | IC50 | = | 3604.72 | nM | 5.44 |
| CHEMBL329650 | — | IC50 | = | 3697.15 | nM | 5.43 |
| CHEMBL1474387 | — | IC50 | = | 4186.31 | nM | 5.38 |
| CHEMBL531742 | — | IC50 | = | 4409.59 | nM | 5.36 |
| CHEMBL103769 | — | IC50 | = | 4824.87 | nM | 5.32 |
| CHEMBL4743495 | — | IC50 | = | 6257.99 | nM | 5.20 |
| CHEMBL238804 | SELEXIPAG | IC50 | > | 10000.0 | nM | - |
| CHEMBL1200517 | DIHYDROERGOTAMINE MESYLATE | IC50 | > | 10000.0 | nM | - |