Assay Detail

CHEMBL5442706

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Functional

GPCR PRESTO-Tango dose-response in antagonist mode with target: AVPR2

ChEMBL ↗

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Target

Vasopressin V2 receptor (CHEMBL1790) ↗

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Vasopressin V2 receptor (CHEMBL1790) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Vasopressin V2 receptor

CHEMBL1790

Anchored from Assay target.

Protein identity Vasopressin V2 receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HTLA
Category	GPCR beta-arrestin recruitment assay
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Vasopressin V2 receptor (CHEMBL1790) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

EUbOPEN Chemogenomics Library - GPCR Dose-Respose

EUbOPEN
(2024)
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.35	8.35

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL344159	TOLVAPTAN	4.0	1	8.35

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL344159	TOLVAPTAN	IC50	=	4.502	nM	8.35