Assay Detail
Functional
CHEMBL5442707
Review assay metadata, readout intent, target linkage, and publication context from the same page.
GPCR PRESTO-Tango dose-response in agonist mode with target: S1PR1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HTLA |
| Category | GPCR beta-arrestin recruitment assay |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
EUbOPEN Chemogenomics Library - GPCR Dose-Respose
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.65 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366208 | FTY720-P | -1.0 | 1 | 9.49 |
| CHEMBL3707247 | OZANIMOD | 4.0 | 1 | 8.47 |
| CHEMBL1938952 | — | — | 1 | 8.00 |
| CHEMBL1672558 | — | — | 1 | 7.64 |
| CHEMBL314854 | FINGOLIMOD | 4.0 | 1 | 7.20 |
| CHEMBL224720 | — | — | 1 | 6.40 |
| CHEMBL1481114 | SPHINGOSYLPHOSPHORYLCHLOLINE | — | 1 | 6.32 |
| CHEMBL3086703 | — | — | 1 | - |
| CHEMBL1384502 | — | — | 1 | - |
| CHEMBL1200517 | DIHYDROERGOTAMINE MESYLATE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366208 | FTY720-P | EC50 | = | 0.3249 | nM | 9.49 |
| CHEMBL3707247 | OZANIMOD | EC50 | = | 3.359 | nM | 8.47 |
| CHEMBL1938952 | — | EC50 | = | 9.999 | nM | 8.00 |
| CHEMBL1672558 | — | EC50 | = | 22.76 | nM | 7.64 |
| CHEMBL314854 | FINGOLIMOD | EC50 | = | 62.65 | nM | 7.20 |
| CHEMBL224720 | — | EC50 | = | 399.0 | nM | 6.40 |
| CHEMBL1481114 | SPHINGOSYLPHOSPHORYLCHLOLINE | EC50 | = | 483.48 | nM | 6.32 |
| CHEMBL3086703 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1384502 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1200517 | DIHYDROERGOTAMINE MESYLATE | EC50 | > | 10000.0 | nM | - |