Assay Detail
Binding
CHEMBL5500463
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Inhibition of DNA topoisomerase II (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Plasmodium falciparum topoisomerases: Emerging targets for anti-malarial therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.13 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1235773 | — | — | 1 | 6.22 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.70 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1235773 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 35000.0 | nM | 4.46 |