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Assay Detail

CHEMBL5500486

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human QG-56 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type QG-56
Confidence 1 — Organism
Curated By Autocuration

Target

QG-56 (CHEMBL612268)
Type CELL-LINE
Organism Homo sapiens

Publication

The potential of marine-derived piperazine alkaloids: Sources, structures and bioactivities.
Zhang Z, Sun Y, Li Y, Song X, Wang R, Zhang D.
Eur J Med Chem (2024) 265 : 116081 -116081
PubMed 38181652 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 6 8.16 9.12

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5557094 1 9.12
CHEMBL451147 RENIERAMYCIN M 1 9.12
CHEMBL5542380 1 8.74
CHEMBL554604 JORUNNAMYCIN C 1 8.55
CHEMBL549905 JOURNNAMYCIN A 1 7.23
CHEMBL5558598 1 6.21

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5557094 IC50 = 0.76 nM 9.12
CHEMBL451147 RENIERAMYCIN M IC50 = 0.76 nM 9.12
CHEMBL5542380 IC50 = 1.8 nM 8.74
CHEMBL554604 JORUNNAMYCIN C IC50 = 2.8 nM 8.55
CHEMBL549905 JOURNNAMYCIN A IC50 = 59.0 nM 7.23
CHEMBL5558598 IC50 = 618.0 nM 6.21