Assay Detail
Binding
CHEMBL5500869
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HPK1 (unknown origin)
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase kinase 1 (CHEMBL5749) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 5-aminopyrido[2,3-d]pyrimidin-7(8H)-one derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.67 | 8.75 |
| IC50 | 3 | 8.91 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5505822 | — | — | 1 | 9.10 |
| CHEMBL5396594 | — | — | 1 | 9.05 |
| CHEMBL5398202 | — | — | 1 | 8.75 |
| CHEMBL5082573 | — | — | 1 | 8.59 |
| CHEMBL4748154 | — | — | 1 | 8.59 |
| CHEMBL5555747 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5505822 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL5396594 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL5398202 | — | Ki | = | 1.76 | nM | 8.75 |
| CHEMBL5082573 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL4748154 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL5555747 | — | Ki | < | 0.05 | nM | - |