Assay Detail
Binding
CHEMBL5500951
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Inhibition of human recombinant GST-tagged ALK5 expressed in baculovirus infected Sf9 insect cells incubated for 60 mins in presence of ATP by microplate scintillation counter
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and anti-liver fibrosis activity of imidazole and thiazole compounds containing amino acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.27 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5558316 | — | — | 1 | 7.85 |
| CHEMBL5517819 | — | — | 1 | 7.77 |
| CHEMBL3261090 | — | — | 1 | 7.66 |
| CHEMBL5517775 | — | — | 1 | 7.64 |
| CHEMBL5512434 | — | — | 1 | 7.64 |
| CHEMBL5558398 | — | — | 1 | 7.60 |
| CHEMBL5556410 | — | — | 1 | 7.44 |
| CHEMBL5549953 | — | — | 1 | 7.40 |
| CHEMBL5517800 | — | — | 1 | 7.21 |
| CHEMBL5557513 | — | — | 1 | 7.18 |
| CHEMBL5517762 | — | — | 1 | 7.14 |
| CHEMBL5557604 | — | — | 1 | 7.08 |
| CHEMBL5558039 | — | — | 1 | 7.06 |
| CHEMBL5555953 | — | — | 1 | 7.04 |
| CHEMBL2364611 | GALUNISERTIB | 2.0 | 1 | 6.89 |
| CHEMBL5532435 | — | — | 1 | 6.50 |
| CHEMBL5517679 | — | — | 1 | 6.42 |
| CHEMBL5555369 | — | — | 1 | - |
| CHEMBL5558988 | — | — | 1 | - |
| CHEMBL5557444 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5558316 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5517819 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3261090 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5517775 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5512434 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5558398 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5556410 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5549953 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5517800 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5557513 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL5517762 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL5557604 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL5558039 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL5555953 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL2364611 | GALUNISERTIB | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL5532435 | — | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL5517679 | — | IC50 | = | 377.0 | nM | 6.42 |
| CHEMBL5555369 | — | IC50 | - | — | - | |
| CHEMBL5558988 | — | IC50 | - | — | - | |
| CHEMBL5557444 | — | IC50 | - | — | - |