Assay Detail
Functional
CHEMBL5501034
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Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
4-Hydroxy-2-pyridone derivatives with antitumor activity produced by mangrove endophytic fungus Talaromyces sp. CY-3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.01 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5556883 | — | — | 1 | 5.46 |
| CHEMBL5512508 | — | — | 1 | 5.42 |
| CHEMBL5559218 | — | — | 1 | 5.41 |
| CHEMBL2179949 | ILICICOLIN H | — | 1 | 5.15 |
| CHEMBL5512596 | — | — | 1 | 5.08 |
| CHEMBL5517747 | — | — | 1 | 5.02 |
| CHEMBL5558944 | — | — | 1 | 4.96 |
| CHEMBL5559537 | — | — | 1 | 4.83 |
| CHEMBL5556641 | — | — | 1 | 4.49 |
| CHEMBL5558413 | — | — | 1 | 4.31 |
| CHEMBL5505867 | — | — | 1 | - |
| CHEMBL5558158 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5556883 | — | IC50 | = | 3460.0 | nM | 5.46 |
| CHEMBL5512508 | — | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL5559218 | — | IC50 | = | 3890.0 | nM | 5.41 |
| CHEMBL2179949 | ILICICOLIN H | IC50 | = | 7010.0 | nM | 5.15 |
| CHEMBL5512596 | — | IC50 | = | 8410.0 | nM | 5.08 |
| CHEMBL5517747 | — | IC50 | = | 9510.0 | nM | 5.02 |
| CHEMBL5558944 | — | IC50 | = | 11050.0 | nM | 4.96 |
| CHEMBL5559537 | — | IC50 | = | 14860.0 | nM | 4.83 |
| CHEMBL5556641 | — | IC50 | = | 32720.0 | nM | 4.49 |
| CHEMBL5558413 | — | IC50 | = | 48910.0 | nM | 4.31 |
| CHEMBL5505867 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5558158 | — | IC50 | > | 50000.0 | nM | - |