Assay Detail
Functional
CHEMBL5501036
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Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-435 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
4-Hydroxy-2-pyridone derivatives with antitumor activity produced by mangrove endophytic fungus Talaromyces sp. CY-3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.98 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5512596 | — | — | 1 | 5.64 |
| CHEMBL5558944 | — | — | 1 | 5.21 |
| CHEMBL2179949 | ILICICOLIN H | — | 1 | 5.20 |
| CHEMBL5505867 | — | — | 1 | 5.16 |
| CHEMBL5559218 | — | — | 1 | 5.14 |
| CHEMBL5512508 | — | — | 1 | 5.04 |
| CHEMBL5559537 | — | — | 1 | 5.03 |
| CHEMBL5556883 | — | — | 1 | 5.00 |
| CHEMBL5556641 | — | — | 1 | 4.69 |
| CHEMBL5517747 | — | — | 1 | 4.61 |
| CHEMBL5558158 | — | — | 1 | 4.53 |
| CHEMBL5558413 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5512596 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5558944 | — | IC50 | = | 6150.0 | nM | 5.21 |
| CHEMBL2179949 | ILICICOLIN H | IC50 | = | 6340.0 | nM | 5.20 |
| CHEMBL5505867 | — | IC50 | = | 6950.0 | nM | 5.16 |
| CHEMBL5559218 | — | IC50 | = | 7290.0 | nM | 5.14 |
| CHEMBL5512508 | — | IC50 | = | 9020.0 | nM | 5.04 |
| CHEMBL5559537 | — | IC50 | = | 9410.0 | nM | 5.03 |
| CHEMBL5556883 | — | IC50 | = | 10030.0 | nM | 5.00 |
| CHEMBL5556641 | — | IC50 | = | 20270.0 | nM | 4.69 |
| CHEMBL5517747 | — | IC50 | = | 24560.0 | nM | 4.61 |
| CHEMBL5558158 | — | IC50 | = | 29460.0 | nM | 4.53 |
| CHEMBL5558413 | — | IC50 | = | 34880.0 | nM | 4.46 |