Assay Detail
Functional
CHEMBL5501115
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Antiproliferative activity against human OVCAR-3 cells assessed as inhibition of cell proliferation incubated for 72 hrs by by CCK-8 assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OVCAR-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of pyrido[3,2-d]pyrimidin-6(5H)-one derivatives as checkpoint kinase 1 (CHK1) inhibitors with potent antitumor efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.22 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5512468 | — | — | 1 | 6.22 |
| CHEMBL4169078 | SRA-737 | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5512468 | — | IC50 | = | 605.5 | nM | 6.22 |
| CHEMBL4169078 | SRA-737 | IC50 | > | 10000.0 | nM | - |