Assay Detail
Functional
CHEMBL5501235
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Antimalarial activity against MMV006833 resistant Plasmodium falciparum 3D7 harboring START1 N330K mutant assessed as reduction in parasite growth incubated for 72 hrs by LDH assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.64 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5558754 | — | — | 1 | 5.80 |
| CHEMBL5505766 | — | — | 1 | 5.77 |
| CHEMBL5542625 | — | — | 1 | 5.68 |
| CHEMBL5505780 | — | — | 1 | 5.66 |
| CHEMBL5505877 | — | — | 1 | 5.58 |
| CHEMBL5558027 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5558754 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5505766 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5542625 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5505780 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5505877 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5558027 | — | EC50 | = | 4400.0 | nM | 5.36 |