Assay Detail
Functional
CHEMBL5501236
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Antimalarial activity against Plasmodium falciparum Dd2 assessed as reduction in parasite growth incubated for 72 hrs by [3H]-hypoxanthine incorporation assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.07 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5505780 | — | — | 1 | 9.00 |
| CHEMBL4091762 | CABAMIQUINE | 2.0 | 1 | 9.00 |
| CHEMBL2058833 | GANAPLACIDE | 2.0 | 1 | 8.10 |
| CHEMBL2041980 | MMV-048 | 2.0 | 1 | 7.80 |
| CHEMBL2431810 | — | — | 1 | 7.68 |
| CHEMBL1956285 | DSM-265 | 2.0 | 1 | 7.62 |
| CHEMBL5557730 | — | — | 1 | 7.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5505780 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4091762 | CABAMIQUINE | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2058833 | GANAPLACIDE | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2041980 | MMV-048 | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2431810 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1956285 | DSM-265 | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5557730 | — | EC50 | = | 54.0 | nM | 7.27 |