Assay Detail
Functional
CHEMBL5501237
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Antimalarial activity against KAF-156 resistant Plasmodium falciparum Dd2 harboring CARL I1139K mutant assessed as reduction in parasite growth incubated for 72 hrs by [3H]-hypoxanthine incorporation assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.47 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5505780 | — | — | 1 | 9.00 |
| CHEMBL5557730 | — | — | 1 | 7.58 |
| CHEMBL2058833 | GANAPLACIDE | 2.0 | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5505780 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5557730 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2058833 | GANAPLACIDE | EC50 | = | 1530.0 | nM | 5.82 |