Assay Detail
ADMET
CHEMBL5501467
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Binding affinity to human serum albumin assessed as equilibrium dissociation constant by SPR analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 5.55 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3971112 | — | — | 1 | 6.07 |
| CHEMBL5532599 | — | — | 1 | 5.79 |
| CHEMBL5557312 | — | — | 1 | 5.45 |
| CHEMBL1464 | WARFARIN | 4.0 | 1 | 5.26 |
| CHEMBL5558492 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3971112 | — | Kd | = | 850.0 | nM | 6.07 |
| CHEMBL5532599 | — | Kd | = | 1640.0 | nM | 5.79 |
| CHEMBL5557312 | — | Kd | = | 3530.0 | nM | 5.45 |
| CHEMBL1464 | WARFARIN | Kd | = | 5500.0 | nM | 5.26 |
| CHEMBL5558492 | — | Kd | = | 6700.0 | nM | 5.17 |