Assay Detail
Functional
CHEMBL5501852
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Antiproliferative activity against human MDA-MB-435 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-435 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of N-(4-((6-(3,5- Dimethoxyphenyl)-9H-purine derivatives as irreversible covalent FGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 4.73 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5558636 | — | — | 1 | 5.48 |
| CHEMBL5532164 | — | — | 1 | 5.25 |
| CHEMBL5523440 | — | — | 1 | 5.23 |
| CHEMBL5556891 | — | — | 1 | 5.20 |
| CHEMBL5557389 | — | — | 1 | 5.04 |
| CHEMBL5518070 | — | — | 1 | 5.00 |
| CHEMBL5523406 | — | — | 1 | 4.95 |
| CHEMBL5555515 | — | — | 1 | 4.89 |
| CHEMBL5556836 | — | — | 1 | 4.88 |
| CHEMBL5532206 | — | — | 1 | 4.80 |
| CHEMBL5287545 | — | — | 1 | 4.79 |
| CHEMBL5557920 | — | — | 1 | 4.73 |
| CHEMBL5517632 | — | — | 1 | 4.72 |
| CHEMBL5532051 | — | — | 1 | 4.70 |
| CHEMBL5532156 | — | — | 1 | 4.68 |
| CHEMBL3348846 | FEXAGRATINIB | 2.0 | 1 | 4.67 |
| CHEMBL5532298 | — | — | 1 | 4.62 |
| CHEMBL5558932 | — | — | 1 | 4.61 |
| CHEMBL5505810 | — | — | 1 | 4.61 |
| CHEMBL5505873 | — | — | 1 | 4.58 |
| CHEMBL5557395 | — | — | 1 | 4.58 |
| CHEMBL5558861 | — | — | 1 | 4.57 |
| CHEMBL5505760 | — | — | 1 | 4.57 |
| CHEMBL5557676 | — | — | 1 | 4.57 |
| CHEMBL5542848 | — | — | 1 | 4.56 |
| CHEMBL5505915 | — | — | 1 | 4.55 |
| CHEMBL5559147 | — | — | 1 | 4.53 |
| CHEMBL5558293 | — | — | 1 | 4.53 |
| CHEMBL5558713 | — | — | 1 | 4.52 |
| CHEMBL5556420 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5558636 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL5532164 | — | IC50 | = | 5670.0 | nM | 5.25 |
| CHEMBL5523440 | — | IC50 | = | 5930.0 | nM | 5.23 |
| CHEMBL5556891 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL5557389 | — | IC50 | = | 9170.0 | nM | 5.04 |
| CHEMBL5518070 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5523406 | — | IC50 | = | 11120.0 | nM | 4.95 |
| CHEMBL5555515 | — | IC50 | = | 12760.0 | nM | 4.89 |
| CHEMBL5556836 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL5532206 | — | IC50 | = | 15670.0 | nM | 4.80 |
| CHEMBL5287545 | — | IC50 | = | 16340.0 | nM | 4.79 |
| CHEMBL5557920 | — | IC50 | = | 18530.0 | nM | 4.73 |
| CHEMBL5517632 | — | IC50 | = | 18910.0 | nM | 4.72 |
| CHEMBL5532051 | — | IC50 | = | 20120.0 | nM | 4.70 |
| CHEMBL5532156 | — | IC50 | = | 20840.0 | nM | 4.68 |
| CHEMBL3348846 | FEXAGRATINIB | IC50 | = | 21580.0 | nM | 4.67 |
| CHEMBL5532298 | — | IC50 | = | 24110.0 | nM | 4.62 |
| CHEMBL5558932 | — | IC50 | = | 24330.0 | nM | 4.61 |
| CHEMBL5505810 | — | IC50 | = | 24550.0 | nM | 4.61 |
| CHEMBL5505873 | — | IC50 | = | 26420.0 | nM | 4.58 |
| CHEMBL5557395 | — | IC50 | = | 26230.0 | nM | 4.58 |
| CHEMBL5558861 | — | IC50 | = | 26960.0 | nM | 4.57 |
| CHEMBL5505760 | — | IC50 | = | 27250.0 | nM | 4.57 |
| CHEMBL5557676 | — | IC50 | = | 27140.0 | nM | 4.57 |
| CHEMBL5542848 | — | IC50 | = | 27390.0 | nM | 4.56 |
| CHEMBL5505915 | — | IC50 | = | 27870.0 | nM | 4.55 |
| CHEMBL5559147 | — | IC50 | = | 29370.0 | nM | 4.53 |
| CHEMBL5558293 | — | IC50 | = | 29390.0 | nM | 4.53 |
| CHEMBL5558713 | — | IC50 | = | 30120.0 | nM | 4.52 |
| CHEMBL5556420 | — | IC50 | = | 30100.0 | nM | 4.52 |
| CHEMBL5555122 | — | IC50 | = | 31560.0 | nM | 4.50 |
| CHEMBL5532250 | — | IC50 | = | 32160.0 | nM | 4.49 |
| CHEMBL5505835 | — | IC50 | = | 32540.0 | nM | 4.49 |
| CHEMBL5523644 | — | IC50 | = | 33760.0 | nM | 4.47 |