Assay Detail
Functional
CHEMBL5501853
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of N-(4-((6-(3,5- Dimethoxyphenyl)-9H-purine derivatives as irreversible covalent FGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 4.84 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5557389 | — | — | 1 | 5.72 |
| CHEMBL5523440 | — | — | 1 | 5.58 |
| CHEMBL5556836 | — | — | 1 | 5.25 |
| CHEMBL5532206 | — | — | 1 | 5.21 |
| CHEMBL5532051 | — | — | 1 | 5.18 |
| CHEMBL5558293 | — | — | 1 | 5.14 |
| CHEMBL3348846 | FEXAGRATINIB | 2.0 | 1 | 5.14 |
| CHEMBL5505810 | — | — | 1 | 5.14 |
| CHEMBL5555515 | — | — | 1 | 5.14 |
| CHEMBL5558713 | — | — | 1 | 5.13 |
| CHEMBL5556420 | — | — | 1 | 5.10 |
| CHEMBL5532298 | — | — | 1 | 5.04 |
| CHEMBL5555122 | — | — | 1 | 5.02 |
| CHEMBL5532250 | — | — | 1 | 5.01 |
| CHEMBL5558861 | — | — | 1 | 5.00 |
| CHEMBL5532164 | — | — | 1 | 5.00 |
| CHEMBL5523406 | — | — | 1 | 4.86 |
| CHEMBL5505835 | — | — | 1 | 4.69 |
| CHEMBL5505873 | — | — | 1 | 4.67 |
| CHEMBL5287545 | — | — | 1 | 4.66 |
| CHEMBL5532156 | — | — | 1 | 4.62 |
| CHEMBL5517632 | — | — | 1 | 4.61 |
| CHEMBL5558932 | — | — | 1 | 4.59 |
| CHEMBL5505760 | — | — | 1 | 4.57 |
| CHEMBL5523644 | — | — | 1 | 4.57 |
| CHEMBL5505915 | — | — | 1 | 4.53 |
| CHEMBL5557676 | — | — | 1 | 4.53 |
| CHEMBL5556891 | — | — | 1 | 4.53 |
| CHEMBL5518070 | — | — | 1 | 4.53 |
| CHEMBL5557920 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5557389 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL5523440 | — | IC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL5556836 | — | IC50 | = | 5640.0 | nM | 5.25 |
| CHEMBL5532206 | — | IC50 | = | 6180.0 | nM | 5.21 |
| CHEMBL5532051 | — | IC50 | = | 6530.0 | nM | 5.18 |
| CHEMBL5558293 | — | IC50 | = | 7170.0 | nM | 5.14 |
| CHEMBL3348846 | FEXAGRATINIB | IC50 | = | 7190.0 | nM | 5.14 |
| CHEMBL5505810 | — | IC50 | = | 7210.0 | nM | 5.14 |
| CHEMBL5555515 | — | IC50 | = | 7220.0 | nM | 5.14 |
| CHEMBL5558713 | — | IC50 | = | 7360.0 | nM | 5.13 |
| CHEMBL5556420 | — | IC50 | = | 7930.0 | nM | 5.10 |
| CHEMBL5532298 | — | IC50 | = | 9150.0 | nM | 5.04 |
| CHEMBL5555122 | — | IC50 | = | 9640.0 | nM | 5.02 |
| CHEMBL5532250 | — | IC50 | = | 9870.0 | nM | 5.01 |
| CHEMBL5532164 | — | IC50 | = | 10060.0 | nM | 5.00 |
| CHEMBL5558861 | — | IC50 | = | 10030.0 | nM | 5.00 |
| CHEMBL5523406 | — | IC50 | = | 13930.0 | nM | 4.86 |
| CHEMBL5505835 | — | IC50 | = | 20280.0 | nM | 4.69 |
| CHEMBL5505873 | — | IC50 | = | 21220.0 | nM | 4.67 |
| CHEMBL5287545 | — | IC50 | = | 22060.0 | nM | 4.66 |
| CHEMBL5532156 | — | IC50 | = | 23760.0 | nM | 4.62 |
| CHEMBL5517632 | — | IC50 | = | 24390.0 | nM | 4.61 |
| CHEMBL5558932 | — | IC50 | = | 25790.0 | nM | 4.59 |
| CHEMBL5505760 | — | IC50 | = | 27240.0 | nM | 4.57 |
| CHEMBL5523644 | — | IC50 | = | 26730.0 | nM | 4.57 |
| CHEMBL5505915 | — | IC50 | = | 29220.0 | nM | 4.53 |
| CHEMBL5557676 | — | IC50 | = | 29340.0 | nM | 4.53 |
| CHEMBL5556891 | — | IC50 | = | 29690.0 | nM | 4.53 |
| CHEMBL5518070 | — | IC50 | = | 29430.0 | nM | 4.53 |
| CHEMBL5557920 | — | IC50 | = | 34760.0 | nM | 4.46 |
| CHEMBL5542848 | — | IC50 | = | 37440.0 | nM | 4.43 |
| CHEMBL5558636 | — | IC50 | = | 39950.0 | nM | 4.40 |
| CHEMBL5557395 | — | IC50 | = | 40270.0 | nM | 4.39 |
| CHEMBL5559147 | — | IC50 | = | 66350.0 | nM | 4.18 |