Assay Detail
Functional
CHEMBL5501855
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Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of N-(4-((6-(3,5- Dimethoxyphenyl)-9H-purine derivatives as irreversible covalent FGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 4.72 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5523440 | — | — | 1 | 5.55 |
| CHEMBL3348846 | FEXAGRATINIB | 2.0 | 1 | 5.50 |
| CHEMBL5557389 | — | — | 1 | 5.10 |
| CHEMBL5556836 | — | — | 1 | 5.08 |
| CHEMBL5523406 | — | — | 1 | 5.03 |
| CHEMBL5555515 | — | — | 1 | 5.03 |
| CHEMBL5287545 | — | — | 1 | 5.02 |
| CHEMBL5532206 | — | — | 1 | 4.95 |
| CHEMBL5505810 | — | — | 1 | 4.95 |
| CHEMBL5532051 | — | — | 1 | 4.91 |
| CHEMBL5532164 | — | — | 1 | 4.80 |
| CHEMBL5556891 | — | — | 1 | 4.79 |
| CHEMBL5532250 | — | — | 1 | 4.75 |
| CHEMBL5558713 | — | — | 1 | 4.72 |
| CHEMBL5505915 | — | — | 1 | 4.70 |
| CHEMBL5505760 | — | — | 1 | 4.63 |
| CHEMBL5532156 | — | — | 1 | 4.62 |
| CHEMBL5558932 | — | — | 1 | 4.61 |
| CHEMBL5557395 | — | — | 1 | 4.60 |
| CHEMBL5557676 | — | — | 1 | 4.57 |
| CHEMBL5555122 | — | — | 1 | 4.57 |
| CHEMBL5505873 | — | — | 1 | 4.56 |
| CHEMBL5558293 | — | — | 1 | 4.56 |
| CHEMBL5542848 | — | — | 1 | 4.55 |
| CHEMBL5532298 | — | — | 1 | 4.54 |
| CHEMBL5556420 | — | — | 1 | 4.54 |
| CHEMBL5558861 | — | — | 1 | 4.53 |
| CHEMBL5505835 | — | — | 1 | 4.52 |
| CHEMBL5517632 | — | — | 1 | 4.40 |
| CHEMBL5518070 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5523440 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL3348846 | FEXAGRATINIB | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL5557389 | — | IC50 | = | 7930.0 | nM | 5.10 |
| CHEMBL5556836 | — | IC50 | = | 8360.0 | nM | 5.08 |
| CHEMBL5523406 | — | IC50 | = | 9260.0 | nM | 5.03 |
| CHEMBL5555515 | — | IC50 | = | 9340.0 | nM | 5.03 |
| CHEMBL5287545 | — | IC50 | = | 9580.0 | nM | 5.02 |
| CHEMBL5532206 | — | IC50 | = | 11130.0 | nM | 4.95 |
| CHEMBL5505810 | — | IC50 | = | 11120.0 | nM | 4.95 |
| CHEMBL5532051 | — | IC50 | = | 12220.0 | nM | 4.91 |
| CHEMBL5532164 | — | IC50 | = | 15730.0 | nM | 4.80 |
| CHEMBL5556891 | — | IC50 | = | 16360.0 | nM | 4.79 |
| CHEMBL5532250 | — | IC50 | = | 17830.0 | nM | 4.75 |
| CHEMBL5558713 | — | IC50 | = | 19080.0 | nM | 4.72 |
| CHEMBL5505915 | — | IC50 | = | 19880.0 | nM | 4.70 |
| CHEMBL5505760 | — | IC50 | = | 23660.0 | nM | 4.63 |
| CHEMBL5532156 | — | IC50 | = | 24210.0 | nM | 4.62 |
| CHEMBL5558932 | — | IC50 | = | 24730.0 | nM | 4.61 |
| CHEMBL5557395 | — | IC50 | = | 25120.0 | nM | 4.60 |
| CHEMBL5557676 | — | IC50 | = | 26820.0 | nM | 4.57 |
| CHEMBL5555122 | — | IC50 | = | 26960.0 | nM | 4.57 |
| CHEMBL5505873 | — | IC50 | = | 27330.0 | nM | 4.56 |
| CHEMBL5558293 | — | IC50 | = | 27590.0 | nM | 4.56 |
| CHEMBL5542848 | — | IC50 | = | 28120.0 | nM | 4.55 |
| CHEMBL5532298 | — | IC50 | = | 29140.0 | nM | 4.54 |
| CHEMBL5556420 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL5558861 | — | IC50 | = | 29580.0 | nM | 4.53 |
| CHEMBL5505835 | — | IC50 | = | 30510.0 | nM | 4.52 |
| CHEMBL5517632 | — | IC50 | = | 39420.0 | nM | 4.40 |
| CHEMBL5518070 | — | IC50 | = | 40050.0 | nM | 4.40 |
| CHEMBL5523644 | — | IC50 | = | 42640.0 | nM | 4.37 |
| CHEMBL5557920 | — | IC50 | = | 45010.0 | nM | 4.35 |
| CHEMBL5559147 | — | IC50 | = | 48400.0 | nM | 4.32 |
| CHEMBL5558636 | — | IC50 | = | 51120.0 | nM | 4.29 |