Assay Detail
Binding
CHEMBL5502104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LIMK2 (unknown origin) assessed as inhibition constant by LanthScreen Eu kinase binding assay
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 46 | 7.21 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5518021 | — | — | 1 | 8.52 |
| CHEMBL5555717 | — | — | 1 | 8.30 |
| CHEMBL5555123 | — | — | 1 | 8.15 |
| CHEMBL5556301 | — | — | 1 | 8.10 |
| CHEMBL5556171 | — | — | 1 | 8.05 |
| CHEMBL5555533 | — | — | 1 | 8.00 |
| CHEMBL5512526 | — | — | 1 | 8.00 |
| CHEMBL5558249 | — | — | 1 | 7.92 |
| CHEMBL5527967 | — | — | 1 | 7.85 |
| CHEMBL5517889 | — | — | 1 | 7.77 |
| CHEMBL5558282 | — | — | 1 | 7.75 |
| CHEMBL5558266 | — | — | 1 | 7.68 |
| CHEMBL5505895 | — | — | 1 | 7.64 |
| CHEMBL5557696 | — | — | 1 | 7.60 |
| CHEMBL5532060 | — | — | 1 | 7.60 |
| CHEMBL5549785 | — | — | 1 | 7.57 |
| CHEMBL5555904 | — | — | 1 | 7.50 |
| CHEMBL5527982 | — | — | 1 | 7.50 |
| CHEMBL5557712 | — | — | 1 | 7.41 |
| CHEMBL5523630 | — | — | 1 | 7.12 |
| CHEMBL5532314 | — | — | 1 | 7.10 |
| CHEMBL5542680 | — | — | 1 | 7.07 |
| CHEMBL5523494 | — | — | 1 | 7.04 |
| CHEMBL5505781 | — | — | 1 | 7.00 |
| CHEMBL5517995 | — | — | 1 | 6.98 |
| CHEMBL5559348 | — | — | 1 | 6.98 |
| CHEMBL5532392 | — | — | 1 | 6.97 |
| CHEMBL5557945 | — | — | 1 | 6.97 |
| CHEMBL5559217 | — | — | 1 | 6.94 |
| CHEMBL5527949 | — | — | 1 | 6.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5518021 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL5555717 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL5555123 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL5556301 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL5556171 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL5555533 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL5512526 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL5558249 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL5527967 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL5517889 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL5558282 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL5558266 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL5505895 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL5557696 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL5532060 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL5549785 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL5555904 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL5527982 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL5557712 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL5523630 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL5532314 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL5542680 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL5523494 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL5505781 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL5559348 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL5517995 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL5532392 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL5557945 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL5559217 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL5527949 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL5556003 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL5543002 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL5555016 | — | Ki | = | 148.0 | nM | 6.83 |
| CHEMBL5558156 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL5537084 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL5558493 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL5505930 | — | Ki | = | 181.0 | nM | 6.74 |
| CHEMBL5559496 | — | Ki | = | 186.0 | nM | 6.73 |
| CHEMBL5555778 | — | Ki | = | 213.0 | nM | 6.67 |
| CHEMBL5505742 | — | Ki | = | 234.0 | nM | 6.63 |
| CHEMBL5558061 | — | Ki | = | 264.0 | nM | 6.58 |
| CHEMBL5558427 | — | Ki | = | 268.0 | nM | 6.57 |
| CHEMBL5559361 | — | Ki | = | 319.0 | nM | 6.50 |
| CHEMBL5523367 | — | Ki | = | 428.0 | nM | 6.37 |
| CHEMBL5518111 | — | Ki | = | 693.0 | nM | 6.16 |
| CHEMBL5542800 | — | Ki | = | 2850.0 | nM | 5.54 |