Assay Detail
Binding
CHEMBL5502129
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Inhibition of GST-fused human LIMK2 (312 to 638 residues) expressed in Sf9 cells incubated for 30 mins by Topcount scintillation counting analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.16 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3182065 | — | — | 1 | 8.22 |
| CHEMBL2141887 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3182065 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2141887 | — | IC50 | = | 8.0 | nM | 8.10 |