Assay Detail
Binding
CHEMBL5502938
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of ARE in human HepG2-ARE-C8 cells incubated for 24 hrs by luciferase based assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2-ARE-C8 |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Discovery of 4-benzylpiperazinequinoline BChE inhibitor that suppresses neuroinflammation for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 4.61 | 4.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5542274 | — | — | 1 | 4.63 |
| CHEMBL242080 | E319 | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5542274 | — | EC50 | = | 23480.0 | nM | 4.63 |
| CHEMBL242080 | E319 | EC50 | = | 25610.0 | nM | 4.59 |