Assay Detail
Functional
CHEMBL5502965
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Inhibition of human TMD8 cells proliferation incubated for 35 to 72 hrs by CellTiter-Glo luminescent cell viability assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TMD8 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.68 | 9.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5557842 | — | — | 1 | 9.38 |
| CHEMBL5557589 | — | — | 1 | 9.20 |
| CHEMBL5555942 | — | — | 1 | 9.18 |
| CHEMBL5518143 | — | — | 1 | 9.12 |
| CHEMBL5532458 | — | — | 1 | 9.09 |
| CHEMBL5527884 | — | — | 1 | 9.03 |
| CHEMBL5537092 | — | — | 1 | 8.75 |
| CHEMBL5532361 | — | — | 1 | 8.62 |
| CHEMBL5517827 | — | — | 1 | 8.53 |
| CHEMBL5558638 | — | — | 1 | 7.90 |
| CHEMBL5532190 | — | — | 1 | 7.74 |
| CHEMBL5555488 | — | — | 1 | 7.58 |
| CHEMBL5556300 | — | — | 1 | - |
| CHEMBL5550053 | — | — | 1 | - |
| CHEMBL5505923 | — | — | 1 | - |
| CHEMBL5557093 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5557842 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL5557589 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL5555942 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL5518143 | — | IC50 | = | 0.76 | nM | 9.12 |
| CHEMBL5532458 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL5527884 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL5537092 | — | IC50 | = | 1.79 | nM | 8.75 |
| CHEMBL5532361 | — | IC50 | = | 2.39 | nM | 8.62 |
| CHEMBL5517827 | — | IC50 | = | 2.94 | nM | 8.53 |
| CHEMBL5558638 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL5532190 | — | IC50 | = | 18.38 | nM | 7.74 |
| CHEMBL5555488 | — | IC50 | = | 26.38 | nM | 7.58 |
| CHEMBL5556300 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5550053 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5505923 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5557093 | — | IC50 | > | 1000.0 | nM | - |