Assay Detail
Functional
CHEMBL5504170
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cell viability in human MDA-MB-231 cells incubated for 4 days by WST-8 assay
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Orally Bioavailable and Potent CDK9 Inhibitors for Targeting Transcription Regulation in Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 6.59 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5557963 | — | — | 1 | 8.23 |
| CHEMBL5559108 | — | — | 1 | 8.19 |
| CHEMBL5527848 | — | — | 1 | 8.09 |
| CHEMBL5531956 | — | — | 1 | 8.07 |
| CHEMBL5542710 | — | — | 1 | 7.97 |
| CHEMBL5558295 | — | — | 1 | 7.95 |
| CHEMBL5558477 | — | — | 1 | 7.94 |
| CHEMBL5527858 | — | — | 1 | 7.90 |
| CHEMBL2103840 | DINACICLIB | 3.0 | 1 | 7.87 |
| CHEMBL5517691 | — | — | 1 | 7.86 |
| CHEMBL5542924 | — | — | 1 | 7.79 |
| CHEMBL5542666 | — | — | 1 | 7.70 |
| CHEMBL5532236 | — | — | 1 | 7.63 |
| CHEMBL5559473 | — | — | 1 | 7.43 |
| CHEMBL5542095 | — | — | 1 | 7.32 |
| CHEMBL5556871 | — | — | 1 | 7.29 |
| CHEMBL5555560 | — | — | 1 | 7.28 |
| CHEMBL5542488 | — | — | 1 | 7.28 |
| CHEMBL5556499 | — | — | 1 | 7.19 |
| CHEMBL5559020 | — | — | 1 | 7.12 |
| CHEMBL5518081 | — | — | 1 | 7.01 |
| CHEMBL5555057 | — | — | 1 | 6.96 |
| CHEMBL5512517 | — | — | 1 | 6.87 |
| CHEMBL5558916 | — | — | 1 | 6.79 |
| CHEMBL5537078 | — | — | 1 | 6.77 |
| CHEMBL5505838 | — | — | 1 | 6.75 |
| CHEMBL5555640 | — | — | 1 | 6.74 |
| CHEMBL5505818 | — | — | 1 | 6.71 |
| CHEMBL5532052 | — | — | 1 | 6.39 |
| CHEMBL5555666 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5557963 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL5559108 | — | IC50 | = | 6.49 | nM | 8.19 |
| CHEMBL5527848 | — | IC50 | = | 8.06 | nM | 8.09 |
| CHEMBL5531956 | — | IC50 | = | 8.55 | nM | 8.07 |
| CHEMBL5542710 | — | IC50 | = | 10.64 | nM | 7.97 |
| CHEMBL5558295 | — | IC50 | = | 11.27 | nM | 7.95 |
| CHEMBL5558477 | — | IC50 | = | 11.43 | nM | 7.94 |
| CHEMBL5527858 | — | IC50 | = | 12.57 | nM | 7.90 |
| CHEMBL2103840 | DINACICLIB | IC50 | = | 13.4 | nM | 7.87 |
| CHEMBL5517691 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL5542924 | — | IC50 | = | 16.15 | nM | 7.79 |
| CHEMBL5542666 | — | IC50 | = | 20.17 | nM | 7.70 |
| CHEMBL5532236 | — | IC50 | = | 23.4 | nM | 7.63 |
| CHEMBL5559473 | — | IC50 | = | 37.38 | nM | 7.43 |
| CHEMBL5542095 | — | IC50 | = | 48.19 | nM | 7.32 |
| CHEMBL5556871 | — | IC50 | = | 50.99 | nM | 7.29 |
| CHEMBL5555560 | — | IC50 | = | 52.53 | nM | 7.28 |
| CHEMBL5542488 | — | IC50 | = | 52.95 | nM | 7.28 |
| CHEMBL5556499 | — | IC50 | = | 64.79 | nM | 7.19 |
| CHEMBL5559020 | — | IC50 | = | 75.58 | nM | 7.12 |
| CHEMBL5518081 | — | IC50 | = | 97.2 | nM | 7.01 |
| CHEMBL5555057 | — | IC50 | = | 109.3 | nM | 6.96 |
| CHEMBL5512517 | — | IC50 | = | 135.8 | nM | 6.87 |
| CHEMBL5558916 | — | IC50 | = | 162.7 | nM | 6.79 |
| CHEMBL5537078 | — | IC50 | = | 170.2 | nM | 6.77 |
| CHEMBL5505838 | — | IC50 | = | 177.6 | nM | 6.75 |
| CHEMBL5555640 | — | IC50 | = | 183.4 | nM | 6.74 |
| CHEMBL5505818 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL5532052 | — | IC50 | = | 404.1 | nM | 6.39 |
| CHEMBL5555666 | — | IC50 | = | 488.5 | nM | 6.31 |
| CHEMBL5537062 | — | IC50 | = | 771.1 | nM | 6.11 |
| CHEMBL5542804 | — | IC50 | = | 859.6 | nM | 6.07 |
| CHEMBL5512555 | — | IC50 | = | 916.7 | nM | 6.04 |
| CHEMBL5556898 | — | IC50 | = | 2361.0 | nM | 5.63 |
| CHEMBL5555502 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL5517798 | — | IC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL5517681 | — | IC50 | = | 3323.0 | nM | 5.48 |
| CHEMBL5532122 | — | IC50 | = | 3532.0 | nM | 5.45 |
| CHEMBL5555405 | — | IC50 | = | 4466.0 | nM | 5.35 |
| CHEMBL5556362 | — | IC50 | = | 4589.0 | nM | 5.34 |
| CHEMBL5512494 | — | IC50 | = | 6894.0 | nM | 5.16 |
| CHEMBL5505745 | — | IC50 | = | 9828.0 | nM | 5.01 |
| CHEMBL5558604 | — | IC50 | = | 9993.0 | nM | 5.00 |
| CHEMBL5523441 | — | IC50 | = | 12610.0 | nM | 4.90 |
| CHEMBL5512510 | — | IC50 | = | 13570.0 | nM | 4.87 |
| CHEMBL5559007 | — | IC50 | = | 19850.0 | nM | 4.70 |
| CHEMBL5557269 | — | IC50 | = | 22350.0 | nM | 4.65 |
| CHEMBL5549863 | — | IC50 | = | 65690.0 | nM | 4.18 |