Assay Detail
Functional
CHEMBL5504174
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Inhibition of cell viability in human MDA-MB-468 cells incubated for 4 days by WST-8 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Orally Bioavailable and Potent CDK9 Inhibitors for Targeting Transcription Regulation in Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.04 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5527848 | — | — | 1 | 8.34 |
| CHEMBL5557963 | — | — | 1 | 8.00 |
| CHEMBL2103840 | DINACICLIB | 3.0 | 1 | 7.93 |
| CHEMBL4462530 | ZEMIRCICLIB | 2.0 | 1 | 7.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5527848 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL5557963 | — | IC50 | = | 10.05 | nM | 8.00 |
| CHEMBL2103840 | DINACICLIB | IC50 | = | 11.85 | nM | 7.93 |
| CHEMBL4462530 | ZEMIRCICLIB | IC50 | = | 13.57 | nM | 7.87 |