Assay Detail
Functional
CHEMBL5504178
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cell viability in human MM1.S cells incubated for 4 days by WST-8 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MM1.S |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Orally Bioavailable and Potent CDK9 Inhibitors for Targeting Transcription Regulation in Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.60 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103840 | DINACICLIB | 3.0 | 1 | 8.44 |
| CHEMBL4462530 | ZEMIRCICLIB | 2.0 | 1 | 8.22 |
| CHEMBL5527848 | — | — | 1 | 8.11 |
| CHEMBL5557963 | — | — | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103840 | DINACICLIB | IC50 | = | 3.63 | nM | 8.44 |
| CHEMBL4462530 | ZEMIRCICLIB | IC50 | = | 6.03 | nM | 8.22 |
| CHEMBL5527848 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL5557963 | — | IC50 | = | 2438.0 | nM | 5.61 |