Assay Detail
Binding
CHEMBL5504235
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mouse GPR18 expressed in CHO cells assessed as activation by measuring beta-arrestin2 recruitment incubated for 90 mins by luminescence based assay
69
Total Activities
69
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent, Selective Agonists for the Cannabinoid-like Orphan G Protein-Coupled Receptor GPR18: A Promising Drug Target for Cancer and Immunity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 69 | 6.45 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5557729 | — | — | 1 | 7.34 |
| CHEMBL5556102 | — | — | 1 | 7.27 |
| CHEMBL5555231 | — | — | 1 | 7.24 |
| CHEMBL5523402 | — | — | 1 | 7.05 |
| CHEMBL5532000 | — | — | 1 | 6.92 |
| CHEMBL5558124 | — | — | 1 | 6.91 |
| CHEMBL5556346 | — | — | 1 | 6.90 |
| CHEMBL5557995 | — | — | 1 | 6.89 |
| CHEMBL5542965 | — | — | 1 | 6.82 |
| CHEMBL5555055 | — | — | 1 | 6.81 |
| CHEMBL5556677 | — | — | 1 | 6.80 |
| CHEMBL5557839 | — | — | 1 | 6.79 |
| CHEMBL5557393 | — | — | 1 | 6.77 |
| CHEMBL5517636 | — | — | 1 | 6.75 |
| CHEMBL5505829 | — | — | 1 | 6.71 |
| CHEMBL5558263 | — | — | 1 | 6.68 |
| CHEMBL5549936 | — | — | 1 | 6.67 |
| CHEMBL5512594 | — | — | 1 | 6.66 |
| CHEMBL5556049 | — | — | 1 | 6.64 |
| CHEMBL5559512 | — | — | 1 | 6.62 |
| CHEMBL5532256 | — | — | 1 | 6.61 |
| CHEMBL5523442 | — | — | 1 | 6.61 |
| CHEMBL5555914 | — | — | 1 | 6.60 |
| CHEMBL5557780 | — | — | 1 | 6.55 |
| CHEMBL5556617 | — | — | 1 | 6.55 |
| CHEMBL5556551 | — | — | 1 | 6.54 |
| CHEMBL5559109 | — | — | 1 | 6.54 |
| CHEMBL5557906 | — | — | 1 | 6.53 |
| CHEMBL5517653 | — | — | 1 | 6.52 |
| CHEMBL5542310 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5557729 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL5556102 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL5555231 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5523402 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5532000 | — | EC50 | = | 121.0 | nM | 6.92 |
| CHEMBL5558124 | — | EC50 | = | 124.0 | nM | 6.91 |
| CHEMBL5556346 | — | EC50 | = | 127.0 | nM | 6.90 |
| CHEMBL5557995 | — | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL5542965 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5555055 | — | EC50 | = | 156.0 | nM | 6.81 |
| CHEMBL5556677 | — | EC50 | = | 157.0 | nM | 6.80 |
| CHEMBL5557839 | — | EC50 | = | 161.0 | nM | 6.79 |
| CHEMBL5557393 | — | EC50 | = | 171.0 | nM | 6.77 |
| CHEMBL5517636 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5505829 | — | EC50 | = | 194.0 | nM | 6.71 |
| CHEMBL5558263 | — | EC50 | = | 207.0 | nM | 6.68 |
| CHEMBL5549936 | — | EC50 | = | 216.0 | nM | 6.67 |
| CHEMBL5512594 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL5556049 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5559512 | — | EC50 | = | 241.0 | nM | 6.62 |
| CHEMBL5532256 | — | EC50 | = | 244.0 | nM | 6.61 |
| CHEMBL5523442 | — | EC50 | = | 245.0 | nM | 6.61 |
| CHEMBL5555914 | — | EC50 | = | 251.0 | nM | 6.60 |
| CHEMBL5557780 | — | EC50 | = | 281.0 | nM | 6.55 |
| CHEMBL5556617 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5556551 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5559109 | — | EC50 | = | 288.0 | nM | 6.54 |
| CHEMBL5557906 | — | EC50 | = | 297.0 | nM | 6.53 |
| CHEMBL5517653 | — | EC50 | = | 299.0 | nM | 6.52 |
| CHEMBL5542310 | — | EC50 | = | 301.0 | nM | 6.52 |
| CHEMBL5523497 | — | EC50 | = | 318.0 | nM | 6.50 |
| CHEMBL5558536 | — | EC50 | = | 334.0 | nM | 6.48 |
| CHEMBL5505756 | — | EC50 | = | 371.0 | nM | 6.43 |
| CHEMBL5505898 | — | EC50 | = | 379.0 | nM | 6.42 |
| CHEMBL5517700 | — | EC50 | = | 379.0 | nM | 6.42 |
| CHEMBL5558192 | — | EC50 | = | 393.0 | nM | 6.41 |
| CHEMBL5556254 | — | EC50 | = | 398.0 | nM | 6.40 |
| CHEMBL5558126 | — | EC50 | = | 444.0 | nM | 6.35 |
| CHEMBL5558903 | — | EC50 | = | 447.0 | nM | 6.35 |
| CHEMBL5557185 | — | EC50 | = | 488.0 | nM | 6.31 |
| CHEMBL5527882 | — | EC50 | = | 559.0 | nM | 6.25 |
| CHEMBL4758188 | — | EC50 | = | 582.0 | nM | 6.24 |
| CHEMBL5523663 | — | EC50 | = | 711.0 | nM | 6.15 |
| CHEMBL5556616 | — | EC50 | = | 981.0 | nM | 6.01 |
| CHEMBL5555175 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5558336 | — | EC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL5556620 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL239232 | — | EC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL5505788 | — | EC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL5557962 | — | EC50 | = | 2970.0 | nM | 5.53 |