Assay Detail
Binding
CHEMBL5504817
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FXIIa (unknown origin) using H-D-Pro-Phe-Arg-pNA as substrate incubated for 20 mins followed by substrate addition by spectrophotometric analysis
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Highly Selective, Potent, Covalent, and Orally Bioavailable Factor XIIa Inhibitors for the Treatment of Thrombo-Inflammation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 7.11 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4776259 | — | — | 1 | 7.46 |
| CHEMBL5556274 | — | — | 1 | 7.43 |
| CHEMBL5557890 | — | — | 1 | 7.41 |
| CHEMBL5559399 | — | — | 1 | 7.40 |
| CHEMBL5556555 | — | — | 1 | 7.32 |
| CHEMBL5523359 | — | — | 1 | 7.30 |
| CHEMBL5558878 | — | — | 1 | 7.29 |
| CHEMBL5517694 | — | — | 1 | 7.25 |
| CHEMBL5523499 | — | — | 1 | 7.14 |
| CHEMBL5549891 | — | — | 1 | 7.10 |
| CHEMBL5558422 | — | — | 1 | 7.09 |
| CHEMBL5558424 | — | — | 1 | 7.07 |
| CHEMBL5542842 | — | — | 1 | 7.02 |
| CHEMBL4761275 | — | — | 1 | 6.79 |
| CHEMBL5550076 | — | — | 1 | 6.75 |
| CHEMBL5557937 | — | — | 1 | 6.72 |
| CHEMBL5517825 | — | — | 1 | 6.71 |
| CHEMBL5558338 | — | — | 1 | 6.70 |
| CHEMBL5531994 | — | — | 1 | - |
| CHEMBL5517943 | — | — | 1 | - |
| CHEMBL5556203 | — | — | 1 | - |
| CHEMBL5542799 | — | — | 1 | - |
| CHEMBL5518152 | — | — | 1 | - |
| CHEMBL5558414 | — | — | 1 | - |
| CHEMBL5556702 | — | — | 1 | - |
| CHEMBL5527965 | — | — | 1 | - |
| CHEMBL5542756 | — | — | 1 | - |
| CHEMBL5532115 | — | — | 1 | - |
| CHEMBL5558001 | — | — | 1 | - |
| CHEMBL5555828 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4776259 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5556274 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5557890 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5559399 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5556555 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5523359 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5558878 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5517694 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5523499 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL5549891 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL5558422 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL5558424 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL5542842 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4761275 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL5550076 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5557937 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5517825 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL5558338 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL5527855 | — | IC50 | - | — | - | |
| CHEMBL5556173 | — | IC50 | - | — | - | |
| CHEMBL5557023 | — | IC50 | - | — | - | |
| CHEMBL5549868 | — | IC50 | - | — | - | |
| CHEMBL5532528 | — | IC50 | - | — | - | |
| CHEMBL5517820 | — | IC50 | - | — | - | |
| CHEMBL5549804 | — | IC50 | - | — | - | |
| CHEMBL5558555 | — | IC50 | - | — | - | |
| CHEMBL5555828 | — | IC50 | - | — | - | |
| CHEMBL5558001 | — | IC50 | - | — | - | |
| CHEMBL5532115 | — | IC50 | - | — | - | |
| CHEMBL5542756 | — | IC50 | - | — | - | |
| CHEMBL5527965 | — | IC50 | - | — | - | |
| CHEMBL5556702 | — | IC50 | - | — | - | |
| CHEMBL5558414 | — | IC50 | - | — | - | |
| CHEMBL5518152 | — | IC50 | - | — | - | |
| CHEMBL5542799 | — | IC50 | - | — | - | |
| CHEMBL5556203 | — | IC50 | - | — | - | |
| CHEMBL5517943 | — | IC50 | - | — | - | |
| CHEMBL5531994 | — | IC50 | - | — | - |