Assay Detail
Binding
CHEMBL5504896
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Inhibition of human FXIIa (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Highly Selective, Potent, Covalent, and Orally Bioavailable Factor XIIa Inhibitors for the Treatment of Thrombo-Inflammation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.43 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5558241 | — | — | 1 | 8.00 |
| CHEMBL5558570 | — | — | 1 | 7.77 |
| CHEMBL5542138 | — | — | 1 | 7.00 |
| CHEMBL4761275 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5558241 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5558570 | — | IC50 | = | 17.1 | nM | 7.77 |
| CHEMBL5542138 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4761275 | — | IC50 | = | 109.0 | nM | 6.96 |