Assay Detail
Binding
CHEMBL5505036
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Inhibition of BCL-2 (unknown origin)/FAM-BIM (unknown origin) interaction measured by fluorescence polarization assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a Covalent Inhibitor That Overcame Resistance to Venetoclax in AML Cells Overexpressing BFL-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.84 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5527957 | — | — | 1 | 8.64 |
| CHEMBL5555333 | — | — | 1 | 8.48 |
| CHEMBL5512573 | — | — | 1 | 8.10 |
| CHEMBL5542092 | — | — | 1 | 8.04 |
| CHEMBL5558580 | — | — | 1 | 5.92 |
| CHEMBL4576854 | — | — | 1 | - |
| CHEMBL5558391 | — | — | 1 | - |
| CHEMBL5523629 | — | — | 1 | - |
| CHEMBL3137309 | VENETOCLAX | 4.0 | 1 | - |
| CHEMBL4788274 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5527957 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL5555333 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL5512573 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL5542092 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL5558580 | — | Ki | = | 1195.0 | nM | 5.92 |
| CHEMBL4576854 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL5558391 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL5523629 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL3137309 | VENETOCLAX | Ki | < | 0.1 | nM | - |
| CHEMBL4788274 | — | Ki | > | 20000.0 | nM | - |