Assay Detail
Functional
CHEMBL5505042
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Antiproliferative activity against human MV4-11 cells expressing high BCL-2 assessed as cell viability measured after 72 hrs by Cell Counting Kit-8 assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Covalent Inhibitor That Overcame Resistance to Venetoclax in AML Cells Overexpressing BFL-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.22 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3137309 | VENETOCLAX | 4.0 | 1 | 6.36 |
| CHEMBL5527957 | — | — | 1 | 5.75 |
| CHEMBL5555333 | — | — | 1 | 5.63 |
| CHEMBL5542092 | — | — | 1 | 5.43 |
| CHEMBL5512573 | — | — | 1 | 5.36 |
| CHEMBL5523629 | — | — | 1 | 4.90 |
| CHEMBL5558391 | — | — | 1 | 4.70 |
| CHEMBL5549784 | — | — | 1 | 4.47 |
| CHEMBL4576854 | — | — | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3137309 | VENETOCLAX | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5527957 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL5555333 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL5542092 | — | IC50 | = | 3690.0 | nM | 5.43 |
| CHEMBL5512573 | — | IC50 | = | 4420.0 | nM | 5.36 |
| CHEMBL5523629 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL5558391 | — | IC50 | = | 19860.0 | nM | 4.70 |
| CHEMBL5549784 | — | IC50 | = | 33520.0 | nM | 4.47 |
| CHEMBL4576854 | — | IC50 | = | 46160.0 | nM | 4.34 |