Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5505340

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antileishmanial activity against Leishmania major promastigotes MHOM/IL/80/Friedlin measured after 72 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania major
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania major (CHEMBL612879)
Type ORGANISM
Organism Leishmania major

Publication

Structure-Activity Study on Substituted, Core-Extended, and Dyad Naphthalene Diimide G-Quadruplex Ligands Leading to Potent Antitrypanosomal Agents.
Benassi A, Peñalver P, Pérez-Soto M, Pirota V, Freccero M, Morales JC, Doria F.
J Med Chem (2024) 67 : 10643 -10654
PubMed 38924701 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.12 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4594805 1 8.70
CHEMBL4095630 1 7.47
CHEMBL5556792 1 6.77
CHEMBL4079866 1 6.61
CHEMBL5505832 1 6.51
CHEMBL4068055 1 6.27
CHEMBL5518020 1 5.60
CHEMBL4597995 1 5.59
CHEMBL5542928 1 5.53
CHEMBL5557014 1 5.42
CHEMBL5531983 1 5.36
CHEMBL255733 1 4.93
CHEMBL5557778 1 4.84
CHEMBL5523407 1 -
CHEMBL5542708 1 -
CHEMBL257367 1 -
CHEMBL5555465 1 -
CHEMBL5557605 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4594805 IC50 = 2.0 nM 8.70
CHEMBL4095630 IC50 = 34.0 nM 7.47
CHEMBL5556792 IC50 = 170.0 nM 6.77
CHEMBL4079866 IC50 = 244.0 nM 6.61
CHEMBL5505832 IC50 = 310.0 nM 6.51
CHEMBL4068055 IC50 = 537.0 nM 6.27
CHEMBL5518020 IC50 = 2490.0 nM 5.60
CHEMBL4597995 IC50 = 2590.0 nM 5.59
CHEMBL5542928 IC50 = 2960.0 nM 5.53
CHEMBL5557014 IC50 = 3760.0 nM 5.42
CHEMBL5531983 IC50 = 4420.0 nM 5.36
CHEMBL255733 IC50 = 11780.0 nM 4.93
CHEMBL5557778 IC50 = 14320.0 nM 4.84
CHEMBL5523407 IC50 > 100000.0 nM -
CHEMBL5542708 IC50 > 100000.0 nM -
CHEMBL257367 IC50 > 100000.0 nM -
CHEMBL5555465 IC50 > 100000.0 nM -
CHEMBL5557605 IC50 > 100000.0 nM -