Assay Detail
Binding
CHEMBL5505639
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human mTOR in presence of ATP
95
Total Activities
95
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of 6-Anilino Imidazo[4,5-<i>c</i>]pyridin-2-ones as Selective DNA-Dependent Protein Kinase Inhibitors and Their Application as Radiosensitizers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 95 | 4.63 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 8.37 |
| CHEMBL4439259 | AZD-7648 | 1.0 | 1 | 5.86 |
| CHEMBL5555639 | — | — | 1 | 5.71 |
| CHEMBL5523655 | — | — | 1 | 5.03 |
| CHEMBL5523360 | — | — | 1 | 5.01 |
| CHEMBL5542141 | — | — | 1 | 4.82 |
| CHEMBL5532026 | — | — | 1 | 4.79 |
| CHEMBL5542587 | — | — | 1 | 4.76 |
| CHEMBL5527864 | — | — | 1 | 4.67 |
| CHEMBL4297629 | NEDISERTIB | 1.0 | 1 | 4.65 |
| CHEMBL5559345 | — | — | 1 | 4.59 |
| CHEMBL5555573 | — | — | 1 | 4.59 |
| CHEMBL5512590 | — | — | 1 | 4.55 |
| CHEMBL5542350 | — | — | 1 | 4.50 |
| CHEMBL5532291 | — | — | 1 | 4.45 |
| CHEMBL5527881 | — | — | 1 | 4.41 |
| CHEMBL5559035 | — | — | 1 | 4.41 |
| CHEMBL5558337 | — | — | 1 | 4.35 |
| CHEMBL5559046 | — | — | 1 | 4.29 |
| CHEMBL5505845 | — | — | 1 | 4.28 |
| CHEMBL5532064 | — | — | 1 | 4.22 |
| CHEMBL5523582 | — | — | 1 | 4.21 |
| CHEMBL5555900 | — | — | 1 | 4.17 |
| CHEMBL5527866 | — | — | 1 | 4.17 |
| CHEMBL5558154 | — | — | 1 | 4.16 |
| CHEMBL5542754 | — | — | 1 | 4.16 |
| CHEMBL5527877 | — | — | 1 | 4.11 |
| CHEMBL5558866 | — | — | 1 | 4.07 |
| CHEMBL5517925 | — | — | 1 | 4.04 |
| CHEMBL5505796 | — | — | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4439259 | AZD-7648 | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL5555639 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL5523655 | — | IC50 | = | 9290.0 | nM | 5.03 |
| CHEMBL5523360 | — | IC50 | = | 9670.0 | nM | 5.01 |
| CHEMBL5542141 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL5532026 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL5542587 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL5527864 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL4297629 | NEDISERTIB | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL5559345 | — | IC50 | = | 25900.0 | nM | 4.59 |
| CHEMBL5555573 | — | IC50 | = | 25900.0 | nM | 4.59 |
| CHEMBL5512590 | — | IC50 | = | 27900.0 | nM | 4.55 |
| CHEMBL5542350 | — | IC50 | = | 31300.0 | nM | 4.50 |
| CHEMBL5532291 | — | IC50 | = | 35700.0 | nM | 4.45 |
| CHEMBL5527881 | — | IC50 | = | 38600.0 | nM | 4.41 |
| CHEMBL5559035 | — | IC50 | = | 39400.0 | nM | 4.41 |
| CHEMBL5558337 | — | IC50 | = | 44800.0 | nM | 4.35 |
| CHEMBL5559046 | — | IC50 | = | 51900.0 | nM | 4.29 |
| CHEMBL5505845 | — | IC50 | = | 52800.0 | nM | 4.28 |
| CHEMBL5532064 | — | IC50 | = | 60200.0 | nM | 4.22 |
| CHEMBL5523582 | — | IC50 | = | 61800.0 | nM | 4.21 |
| CHEMBL5555900 | — | IC50 | = | 67400.0 | nM | 4.17 |
| CHEMBL5527866 | — | IC50 | = | 68100.0 | nM | 4.17 |
| CHEMBL5542754 | — | IC50 | = | 68800.0 | nM | 4.16 |
| CHEMBL5558154 | — | IC50 | = | 69200.0 | nM | 4.16 |
| CHEMBL5527877 | — | IC50 | = | 77630.0 | nM | 4.11 |
| CHEMBL5558866 | — | IC50 | = | 85700.0 | nM | 4.07 |
| CHEMBL5517925 | — | IC50 | = | 90500.0 | nM | 4.04 |
| CHEMBL5505796 | — | IC50 | = | 92500.0 | nM | 4.03 |
| CHEMBL5558917 | — | IC50 | = | 96600.0 | nM | 4.01 |
| CHEMBL5558518 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5559285 | — | IC50 | - | — | - | |
| CHEMBL5517961 | — | IC50 | - | — | - | |
| CHEMBL5523384 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5518018 | — | IC50 | - | — | - | |
| CHEMBL5557807 | — | IC50 | - | — | - | |
| CHEMBL5542181 | — | IC50 | - | — | - | |
| CHEMBL5556556 | — | IC50 | - | — | - | |
| CHEMBL5518025 | — | IC50 | - | — | - | |
| CHEMBL5542679 | — | IC50 | - | — | - | |
| CHEMBL5559203 | — | IC50 | - | — | - | |
| CHEMBL5542841 | — | IC50 | - | — | - | |
| CHEMBL5557413 | — | IC50 | - | — | - | |
| CHEMBL5556014 | — | IC50 | - | — | - | |
| CHEMBL5505751 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5532012 | — | IC50 | - | — | - | |
| CHEMBL5532276 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5537087 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5542179 | — | IC50 | > | 100000.0 | nM | - |