Assay Detail
Functional
CHEMBL5505657
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of radiosensitization against human HCT116/54C cells assessed as potentiation of radiation-induced cytotoxicity pre-irradiated with gamma radiation at 3 Gy followed by incubation with drug for 1 hr and measured after 18 hrs by SRB method normalized to radiation only
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT116/54C |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of 6-Anilino Imidazo[4,5-<i>c</i>]pyridin-2-ones as Selective DNA-Dependent Protein Kinase Inhibitors and Their Application as Radiosensitizers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.14 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4439259 | AZD-7648 | 1.0 | 1 | 7.21 |
| CHEMBL5527881 | — | — | 1 | 6.68 |
| CHEMBL5532026 | — | — | 1 | 6.68 |
| CHEMBL5558866 | — | — | 1 | 6.66 |
| CHEMBL4297629 | NEDISERTIB | 1.0 | 1 | 6.58 |
| CHEMBL5531947 | — | — | 1 | 6.51 |
| CHEMBL5559388 | — | — | 1 | 6.43 |
| CHEMBL5556014 | — | — | 1 | 6.40 |
| CHEMBL5517961 | — | — | 1 | 6.40 |
| CHEMBL5542350 | — | — | 1 | 6.27 |
| CHEMBL5542587 | — | — | 1 | 6.08 |
| CHEMBL5559345 | — | — | 1 | 6.05 |
| CHEMBL5559285 | — | — | 1 | 6.03 |
| CHEMBL5558337 | — | — | 1 | 5.86 |
| CHEMBL5523360 | — | — | 1 | 5.84 |
| CHEMBL5517925 | — | — | 1 | 5.77 |
| CHEMBL5523472 | — | — | 1 | 5.68 |
| CHEMBL5543038 | — | — | 1 | 5.32 |
| CHEMBL5542141 | — | — | 1 | 5.20 |
| CHEMBL5532012 | — | — | 1 | 5.13 |
| CHEMBL5532346 | — | — | 1 | - |
| CHEMBL5555156 | — | — | 1 | - |
| CHEMBL6067692 | — | — | 1 | - |
| CHEMBL5558970 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4439259 | AZD-7648 | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5527881 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5532026 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5558866 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4297629 | NEDISERTIB | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5531947 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5559388 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5556014 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5517961 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5542350 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5542587 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL5559345 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL5559285 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL5558337 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL5523360 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL5517925 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL5523472 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5543038 | — | IC50 | = | 4760.0 | nM | 5.32 |
| CHEMBL5542141 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL5532012 | — | IC50 | = | 7410.0 | nM | 5.13 |
| CHEMBL5532346 | — | IC50 | - | — | - | |
| CHEMBL5555156 | — | IC50 | - | — | - | |
| CHEMBL6067692 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5558970 | — | IC50 | > | 10000.0 | nM | - |