Assay Detail
Functional
CHEMBL5505658
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of radiosensitization against human HAP1 cells assessed as potentiation of radiation-induced cytotoxicity pre-irradiated with gamma radiation at 3 Gy followed by incubation with drug for 1 hr and measured after 18 hrs by SRB method normalized to radiation only
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HAP1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of 6-Anilino Imidazo[4,5-<i>c</i>]pyridin-2-ones as Selective DNA-Dependent Protein Kinase Inhibitors and Their Application as Radiosensitizers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.76 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4439259 | AZD-7648 | 1.0 | 1 | 7.24 |
| CHEMBL4297629 | NEDISERTIB | 1.0 | 1 | 7.22 |
| CHEMBL5542350 | — | — | 1 | 6.62 |
| CHEMBL5523360 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4439259 | AZD-7648 | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4297629 | NEDISERTIB | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5542350 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5523360 | — | IC50 | = | 1090.0 | nM | 5.96 |