Assay Detail
Binding
CHEMBL5505732
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Inhibition of C-terminal Hexa-histidine-tagged human recombinant IRAP expressed in Sf9 cells using R-AMC as substrate incubated for 15 mins by Michaelis-Menten analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
ERAP Inhibitors in Autoimmunity and Immuno-Oncology: Medicinal Chemistry Insights.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.35 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL448735 | — | — | 1 | 8.10 |
| CHEMBL28650 | AMASTATIN | — | 1 | 4.60 |
| CHEMBL29292 | UBENIMEX | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL448735 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL28650 | AMASTATIN | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL29292 | UBENIMEX | IC50 | > | 100000.0 | nM | - |