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Assay Detail

CHEMBL5505735

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant Leucine aminopeptidase 3
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cytosol aminopeptidase (CHEMBL3965)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

ERAP Inhibitors in Autoimmunity and Immuno-Oncology: Medicinal Chemistry Insights.
Fougiaxis V, He B, Khan T, Vatinel R, Koutroumpa NM, Afantitis A, Lesire L, Sierocki P, Deprez B, Deprez-Poulain R.
J Med Chem (2024) 67 : 11597 -11621
PubMed 39011823 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 8.80 9.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL29292 UBENIMEX 2.0 1 9.30
CHEMBL2103847 TOSEDOSTAT 2.0 1 8.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL29292 UBENIMEX IC50 = 0.5 nM 9.30
CHEMBL2103847 TOSEDOSTAT IC50 = 5.0 nM 8.30