Assay Detail
Binding
CHEMBL5506075
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Inhibition of JAK2 V617F mutant (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and clinical application of small-molecule inhibitors of Janus kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.89 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1287853 | FEDRATINIB | 4.0 | 1 | 8.52 |
| CHEMBL2107823 | GANDOTINIB | 2.0 | 1 | 7.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1287853 | FEDRATINIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2107823 | GANDOTINIB | IC50 | = | 55.0 | nM | 7.26 |