Assay Detail
Binding
CHEMBL5506079
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Inhibition of JAK1 (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and clinical application of small-molecule inhibitors of Janus kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.82 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3622820 | ITACITINIB | 3.0 | 1 | 8.70 |
| CHEMBL2105759 | BARICITINIB | 4.0 | 1 | 8.23 |
| CHEMBL3301607 | FILGOTINIB | 4.0 | 1 | 8.00 |
| CHEMBL4303389 | NS-018 | 2.0 | 1 | 7.48 |
| CHEMBL3622821 | UPADACITINIB | 4.0 | 1 | 7.37 |
| CHEMBL4577523 | GOLIDOCITINIB | 2.0 | 1 | 7.14 |
| CHEMBL4085457 | RITLECITINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3622820 | ITACITINIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2105759 | BARICITINIB | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL3301607 | FILGOTINIB | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4303389 | NS-018 | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3622821 | UPADACITINIB | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4577523 | GOLIDOCITINIB | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4085457 | RITLECITINIB | IC50 | > | 10000.0 | nM | - |