Assay Detail
Binding
CHEMBL5506080
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Inhibition of JAK2 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and clinical application of small-molecule inhibitors of Janus kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.95 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105759 | BARICITINIB | 4.0 | 1 | 8.24 |
| CHEMBL3301607 | FILGOTINIB | 4.0 | 1 | 7.55 |
| CHEMBL2107823 | GANDOTINIB | 2.0 | 1 | 7.17 |
| CHEMBL4577523 | GOLIDOCITINIB | 2.0 | 1 | 4.83 |
| CHEMBL4085457 | RITLECITINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105759 | BARICITINIB | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL3301607 | FILGOTINIB | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2107823 | GANDOTINIB | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL4577523 | GOLIDOCITINIB | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL4085457 | RITLECITINIB | IC50 | > | 10000.0 | nM | - |