Assay Detail
Functional
CHEMBL5506180
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 WA1/2020 infected in human Calu-3 cells preincubated for 2 hrs followed by viral infection and measured after 48 hrs by microscopy analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Targeting SARS-CoV-2 entry processes: The promising potential and future of host-targeted small-molecule inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.91 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5557224 | — | — | 1 | 7.28 |
| CHEMBL5557776 | — | — | 1 | 7.13 |
| CHEMBL5567734 | — | — | 1 | 6.99 |
| CHEMBL5559530 | — | — | 1 | 6.98 |
| CHEMBL5081508 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5557224 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL5557776 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL5567734 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL5559530 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL5081508 | — | IC50 | = | 660.0 | nM | 6.18 |