Assay Detail
Binding
CHEMBL5506183
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Binding affinity to CRBN (unknown origin) assessed as dissociation constant by TR-FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Facilitating the development of molecular glues: Opportunities from serendipity and rational design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.72 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43452 | POMALIDOMIDE | 4.0 | 1 | 6.80 |
| CHEMBL848 | LENALIDOMIDE | 4.0 | 1 | 6.75 |
| CHEMBL468 | THALIDOMIDE | 4.0 | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43452 | POMALIDOMIDE | Kd | = | 157.0 | nM | 6.80 |
| CHEMBL848 | LENALIDOMIDE | Kd | = | 178.0 | nM | 6.75 |
| CHEMBL468 | THALIDOMIDE | Kd | = | 250.0 | nM | 6.60 |