Assay Detail
Binding
CHEMBL5506263
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant LSD1 using H3K4me2 as peptide substrate incubated for 30 mins by fluorescence based analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 1A (CHEMBL6136) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Exploring the potential of histone demethylase inhibition in multi-therapeutic approaches for cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.80 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3906257 | — | — | 1 | 8.80 |
| CHEMBL4802155 | VAFIDEMSTAT | 2.0 | 1 | 8.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3906257 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4802155 | VAFIDEMSTAT | IC50 | = | 1.6 | nM | 8.80 |