Assay Detail
Functional
CHEMBL5506674
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Antiproliferative activity against human MV4-11 cells harboring wild type p53 assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based fluorescence analysis
30
Total Activities
26
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
HDAC/NAMPT dual inhibitors overcome initial drug-resistance in p53-null leukemia cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.91 | 7.82 |
| GI50 | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | 2.0 | 2 | 7.82 |
| CHEMBL5083249 | — | — | 2 | 7.72 |
| CHEMBL5532146 | — | — | 2 | 7.53 |
| CHEMBL5559648 | — | — | 1 | 7.50 |
| CHEMBL5561596 | — | — | 1 | 7.50 |
| CHEMBL5556752 | — | — | 1 | 7.48 |
| CHEMBL5078985 | — | — | 1 | 7.43 |
| CHEMBL5087431 | — | — | 1 | 7.35 |
| CHEMBL5557716 | — | — | 1 | 7.28 |
| CHEMBL5559070 | — | — | 2 | 7.22 |
| CHEMBL5558823 | — | — | 1 | 7.17 |
| CHEMBL5561465 | — | — | 1 | 7.07 |
| CHEMBL5568033 | — | — | 1 | 7.06 |
| CHEMBL5532409 | — | — | 1 | 6.76 |
| CHEMBL5550071 | — | — | 1 | 6.36 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.27 |
| CHEMBL5563379 | — | — | 1 | 6.18 |
| CHEMBL5532078 | — | — | 1 | 6.10 |
| CHEMBL5560674 | — | — | 1 | 6.04 |
| CHEMBL5555272 | — | — | 1 | 5.66 |
| CHEMBL5557041 | — | — | 1 | 5.65 |
| CHEMBL5560853 | — | — | 1 | - |
| CHEMBL5565699 | — | — | 1 | - |
| CHEMBL5560296 | — | — | 1 | - |
| CHEMBL5558311 | — | — | 1 | - |
| CHEMBL4526892 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL5083249 | — | IC50 | = | 19.2 | nM | 7.72 |
| CHEMBL5532146 | — | IC50 | = | 29.6 | nM | 7.53 |
| CHEMBL5559648 | — | IC50 | = | 31.4 | nM | 7.50 |
| CHEMBL5561596 | — | IC50 | = | 31.3 | nM | 7.50 |
| CHEMBL5556752 | — | IC50 | = | 32.9 | nM | 7.48 |
| CHEMBL5078985 | — | IC50 | = | 36.9 | nM | 7.43 |
| CHEMBL5087431 | — | IC50 | = | 44.6 | nM | 7.35 |
| CHEMBL5557716 | — | IC50 | = | 52.4 | nM | 7.28 |
| CHEMBL5559070 | — | IC50 | = | 60.8 | nM | 7.22 |
| CHEMBL5558823 | — | IC50 | = | 67.7 | nM | 7.17 |
| CHEMBL5561465 | — | IC50 | = | 85.2 | nM | 7.07 |
| CHEMBL5568033 | — | IC50 | = | 87.7 | nM | 7.06 |
| CHEMBL5532409 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL5550071 | — | IC50 | = | 434.3 | nM | 6.36 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 537.0 | nM | 6.27 |
| CHEMBL5563379 | — | IC50 | = | 667.0 | nM | 6.18 |
| CHEMBL5532078 | — | IC50 | = | 789.0 | nM | 6.10 |
| CHEMBL5560674 | — | IC50 | = | 901.0 | nM | 6.04 |
| CHEMBL5555272 | — | IC50 | = | 2192.0 | nM | 5.66 |
| CHEMBL5557041 | — | IC50 | = | 2235.0 | nM | 5.65 |
| CHEMBL5560853 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5565699 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5560296 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5558311 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5559070 | — | GI50 | = | 38.3 | nM | - |
| CHEMBL5532146 | — | GI50 | = | 23.6 | nM | - |
| CHEMBL5083249 | — | GI50 | = | 37.3 | nM | - |
| CHEMBL566757 | DAPORINAD | GI50 | = | 7.95 | nM | - |
| CHEMBL4526892 | — | GI50 | = | 16.0 | nM | - |