Assay Detail
Functional
CHEMBL5506730
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat mGluR5 receptor expressed in HEK293 cells by IP-1 HTRF assay
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 5 (CHEMBL2564) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacological characterization of conformationally restricted 2-amino-Adipic acid analogs and carboxycyclopropyl glycines as selective metabotropic glutamate 2 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.96 | 4.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5532032 | — | — | 2 | 4.97 |
| CHEMBL5555290 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5532032 | — | EC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL5532032 | — | EC50 | = | 11220.18 | nM | 4.95 |
| CHEMBL5555290 | — | EC50 | > | 30000.0 | nM | - |