Assay Detail
Functional
CHEMBL5506736
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat mGluR3 receptor expressed in HEK293 cells by IP-1 HTRF assay
5
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 3 (CHEMBL3067) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacological characterization of conformationally restricted 2-amino-Adipic acid analogs and carboxycyclopropyl glycines as selective metabotropic glutamate 2 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.98 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275079 | LY-379268 | — | 2 | 8.05 |
| CHEMBL5532032 | — | — | 2 | 5.91 |
| CHEMBL5555290 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275079 | LY-379268 | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL275079 | LY-379268 | EC50 | = | 9.333 | nM | 8.03 |
| CHEMBL5532032 | — | EC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL5532032 | — | EC50 | = | 1230.27 | nM | 5.91 |
| CHEMBL5555290 | — | EC50 | > | 30000.0 | nM | - |