Assay Detail
Functional
CHEMBL5506767
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Inhibition of melanogenesis in human MNT-1 cells incubated for 4 days
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MNT-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of 4-amino-2',4'-dihydroxyindanone derivatives as potent inhibitors of tyrosinase and melanin biosynthesis in human melanoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.95 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5557324 | — | — | 1 | 5.50 |
| CHEMBL5556099 | — | — | 1 | 5.42 |
| CHEMBL5566780 | — | — | 1 | 5.16 |
| CHEMBL5558420 | — | — | 1 | 5.10 |
| CHEMBL4743159 | — | — | 1 | 5.00 |
| CHEMBL5562348 | — | — | 1 | 4.72 |
| CHEMBL5557086 | — | — | 1 | 4.72 |
| CHEMBL5563317 | — | — | 1 | 4.68 |
| CHEMBL5555033 | — | — | 1 | 4.62 |
| CHEMBL5566466 | — | — | 1 | 4.54 |
| CHEMBL287556 | KOJIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5557324 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL5556099 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL5566780 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL5558420 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4743159 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5562348 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL5557086 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL5563317 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL5555033 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL5566466 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 14000000.0 | nM | - |