Assay Detail
Functional
CHEMBL5506768
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Inhibition of melanogenesis in human MNT-1 cells incubated for 14 days
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MNT-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of 4-amino-2',4'-dihydroxyindanone derivatives as potent inhibitors of tyrosinase and melanin biosynthesis in human melanoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.70 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4743159 | — | — | 1 | 6.55 |
| CHEMBL5556099 | — | — | 1 | 6.28 |
| CHEMBL5557324 | — | — | 1 | 6.11 |
| CHEMBL5555033 | — | — | 1 | 5.70 |
| CHEMBL5566780 | — | — | 1 | 5.68 |
| CHEMBL5558420 | — | — | 1 | 5.51 |
| CHEMBL5562348 | — | — | 1 | 5.48 |
| CHEMBL5563317 | — | — | 1 | 5.39 |
| CHEMBL5557086 | — | — | 1 | 5.34 |
| CHEMBL5566466 | — | — | 1 | 4.92 |
| CHEMBL287556 | KOJIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4743159 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5556099 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5557324 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL5555033 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5566780 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5558420 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5562348 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL5563317 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5557086 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5566466 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 800000.0 | nM | - |