Assay Detail
Functional
CHEMBL5506813
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against sorbitol-synchronized ring stage atovaquone resistant Plasmodium falciparum TM90C6B harboring Y268S mutation in CYTB gene, Y184F mutation in MDR1 gene, N51I/C59R/S108N mutation in DHFR gene and S436F/A437G/A581G mutation in DHPS gene infected in erythrocytes measured after 48 hrs by SYBR green dye based fluorescence analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | Erythrocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of new piperaquine hybrid analogs linked by triazolopyrimidine and pyrazolopyrimidine scaffolds with antiplasmodial and transmission blocking activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.95 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5557769 | — | — | 1 | 7.40 |
| CHEMBL5559121 | — | — | 1 | 6.75 |
| CHEMBL5560017 | — | — | 1 | 6.70 |
| CHEMBL5559610 | — | — | 1 | - |
| CHEMBL5563645 | — | — | 1 | - |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | - |
| CHEMBL1956285 | DSM-265 | 2.0 | 1 | - |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5557769 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5559121 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5560017 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5559610 | — | IC50 | - | — | - | |
| CHEMBL5563645 | — | IC50 | - | — | - | |
| CHEMBL76 | CHLOROQUINE | IC50 | - | — | - | |
| CHEMBL1956285 | DSM-265 | IC50 | - | — | - | |
| CHEMBL1450 | ATOVAQUONE | IC50 | > | 1000.0 | nM | - |