Assay Detail
Functional
CHEMBL5506815
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against sorbitol-synchronized ring stage 2-(1,1-difluoroethyl)-5-methyl-N-(4-(pentafluoro-l6-sulfaneyl)phenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine resistant Plasmodium falciparum Dd2 infected in erythrocytes measured after 48 hrs by SYBR green dye based fluorescence analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | Erythrocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of new piperaquine hybrid analogs linked by triazolopyrimidine and pyrazolopyrimidine scaffolds with antiplasmodial and transmission blocking activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.17 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1956285 | DSM-265 | 2.0 | 1 | 7.92 |
| CHEMBL5557769 | — | — | 1 | 7.30 |
| CHEMBL5559121 | — | — | 1 | 6.82 |
| CHEMBL5560017 | — | — | 1 | 6.64 |
| CHEMBL5559610 | — | — | 1 | - |
| CHEMBL5563645 | — | — | 1 | - |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | - |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1956285 | DSM-265 | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5557769 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5559121 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5560017 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5559610 | — | IC50 | - | — | - | |
| CHEMBL5563645 | — | IC50 | - | — | - | |
| CHEMBL76 | CHLOROQUINE | IC50 | - | — | - | |
| CHEMBL1450 | ATOVAQUONE | IC50 | - | — | - |