Assay Detail
Binding
CHEMBL5506832
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Inhibition of human full length recombinant ATR M211T mutant using GST-c-Myc-p53 as substrate measured after 30 mins in presence of Mg/ATP mix by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of the Potent and Selective ATR Inhibitor Camonsertib (RP-3500).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.72 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3989870 | BERZOSERTIB | 2.0 | 1 | 8.30 |
| CHEMBL2325697 | — | — | 1 | 8.00 |
| CHEMBL4285417 | CERALASERTIB | 3.0 | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3989870 | BERZOSERTIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2325697 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4285417 | CERALASERTIB | IC50 | = | 134.0 | nM | 6.87 |